The Coronavirus outbreak has a profoundly effect on the daily practice of Amsterdam UMC personnel in a relatively short time frame. However, the many promising initiatives taken by our personnel show enormous adaptive power, creativity and perseverance. Not only the doctors, nurses and supporting staff work around the clock to provide the best care for our patients. Also, behind the scenes, many researchers have joined forces to battle COVID-19 in an agile manner and without any reluctance. The way in which Amsterdam UMC researchers have responded to the pandemic has demonstrated the importance of team science in trying to make this worldwide crisis manageable.