CTTI will discuss its current work to obtain reliability and acceptance of meaningful, digitally derived novel endpoints – a project that builds on its existing novel endpoint recommendations and resources. This includes highlights from a recent Expert Meeting of leaders and stakeholders from across the clinical trials ecosystem, and a preview of the forthcoming set of CTTI novel endpoint recommendations and resources. This is the third installment in a series of novel digital endpoint webinars brought to you by CTTI, DiMe, and TransCelerate.