The (early) clinical development of new analgesics: the point of view of a pain clinician. In the first part of this webinar an overview will be provided of the wide “landscape” of pain syndromes. Next to the current understanding of the pathophysiology of pain and the basic processes of nociception, the main limitations of the current analgesics will be discussed. Based on these limitations an overview will be presented about the explorative research pipelines into new targets to tackle pain. Many of these targets will soon become or are already under investigation in early clinical drug development trials.